over the human life course Genetic and environmental exposures constrain epigenetic drift
نویسندگان
چکیده
Material Supplemental http://genome.cshlp.org/content/suppl/2014/09/17/gr.176933.114.DC1.html P<P Published online September 23, 2014 in advance of the print journal. Manuscript Accepted manuscript is likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; accepted License Commons Creative . http://creativecommons.org/licenses/by-nc/4.0/ described at a Creative Commons License (Attribution-NonCommercial 4.0 International), as ). After six months, it is available under http://genome.cshlp.org/site/misc/terms.xhtml first six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the
منابع مشابه
Genetic and environmental exposures constrain epigenetic drift over the human life course.
Epigenetic mechanisms such as DNA methylation (DNAm) are essential for regulation of gene expression. DNAm is dynamic, influenced by both environmental and genetic factors. Epigenetic drift is the divergence of the epigenome as a function of age due to stochastic changes in methylation. Here we show that epigenetic drift may be constrained at many CpGs across the human genome by DNA sequence va...
متن کاملEpigenetics, Behaviour, and Health
: The long-term effects of behaviour and environmental exposures, particularly during childhood, on health outcomes are well documented. Particularly thought provoking is the notion that exposures to different social environments have a long-lasting impact on human physical health. However, the mechanisms mediating the effects of the environment are still unclear. In the last decade, the main f...
متن کاملDNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome.
Mounting evidence from both animal and human studies suggests that the epigenome is in constant drift over the life course in response to stochastic and environmental factors. In humans, this has been highlighted by a small number of studies that have demonstrated discordant DNA methylation patterns in adolescent or adult monozygotic (MZ) twin pairs. However, to date, it remains unclear when su...
متن کاملEnvironmental Deflection: The Impact of Toxicant Exposures on the Aging Epigenome.
Epigenetic drift and age-related methylation have both been used in the literature to describe changes in DNA methylation that occurs with aging. However, ambiguity remains regarding the exact definition of both of these terms, and neither of these fields of study explicitly considers the impact of environmental factors on the aging epigenome. Recent twin studies have demonstrated longitudinal,...
متن کاملتئوریهای بیوشیمیایی و ژنتیکی فرایند پیری
Aging is the outcome of the progressive accumulation of different alterations in the body which accompanied with gradual decrease of the efficiencies of normal physiological functions and the capacity to maintain homeostasis that lead to the increase in disease probability and the death of people. The researchers have done different experiments especially on animal models for the perception of ...
متن کامل